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Investigating idiopathic inflammatory myopathy; initial cross speciality experience with use of the extended myositis antibody panel

Antoinette O'Connor, Jennifer Mulhall, Sinead M.J. Harney, John G. Ryan, Grainne Murphy, Michael T. Henry, Peter Annis, Vincent Tormey, Aisling Ryan
  • Jennifer Mulhall
    Department of Neurology, Cork University Hospital, Cork, Ireland
  • Sinead M.J. Harney
    Department of Rheumatology, Cork University Hospital, Cork, Ireland
  • John G. Ryan
    Department of Rheumatology, Cork University Hospital, Cork, Ireland
  • Grainne Murphy
    Department of Rheumatology, Cork University Hospital, Cork, Ireland
  • Michael T. Henry
    Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland
  • Peter Annis
    Department of Immunology, Cork University Hospital, Cork, Ireland
  • Vincent Tormey
    Department of Immunology, University Hospital, Galway, Ireland
  • Aisling Ryan
    Department of Neurology, Cork University Hospital, Cork, Ireland

Abstract

The discovery of unique autoantibodies has informed and altered our approach to the diagnosis and management of the inflammatory myopathies. This study reports the initial clinical experience of use of the Extended Myositis Antibody (EMA) panel in the largest university teaching hospital in Ireland. We conducted a retrospective review of all patients who had serum samples tested for myositis specific antibodies and myositis associated antibodies from April 2014 to March 2015. A positive EMA panel was of significant clinical utility in facilitating decisions on appropriate investigations, and need for onward referral to other physicians. Furthermore, this paper highlights the diversity of possible presentations of idiopathic inflammatory myopathy with subsequent need for multi-speciality involvement, and serves to heighten awareness among clinicians of the diagnostic use of extended myositis antibody testing in these cases.

Keywords

Idiopathic inflammatory myopathy; myositis specific autoantibodies; myositis- associated autoantibodies.

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Submitted: 2016-10-23 19:00:26
Published: 2017-05-04 14:20:41
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Copyright (c) 2017 Antoinette O’Connor, Jennifer Mulhall, Sinead M.J. Harney, John G. Ryan, Grainne Murphy, Michael T. Henry, Peter Annis, Vincent Tormey, Aisling M. Ryan

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