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Gut microbiota’s effect on mental health: The gut-brain axis

Megan Clapp, Nadia Aurora, Lindsey Herrera, Manisha Bhatia, Emily Wilen, Sarah Wakefield
  • Megan Clapp
    School of Medicine, Health Sciences Center, Texas Tech University, TX, United States | megan.clapp@ttuhsc.edu
  • Nadia Aurora
    School of Medicine, Health Sciences Center, Texas Tech University, TX, United States
  • Lindsey Herrera
    School of Medicine, Health Sciences Center, Texas Tech University, TX, United States
  • Manisha Bhatia
    School of Medicine, Health Sciences Center, Texas Tech University, TX, United States
  • Emily Wilen
    School of Medicine, Health Sciences Center, Texas Tech University, TX, United States
  • Sarah Wakefield
    Department of Psychiatry, Health Sciences Center, Texas Tech University, TX, United States

Abstract

The bidirectional communication between the central nervous system and gut microbiota, referred to as the gut-brain-axis, has been of significant interest in recent years. Increasing evidence has associated gut microbiota to both gastrointestinal and extragastrointestinal diseases. Dysbiosis and inflammation of the gut have been linked to causing several mental illnesses including anxiety and depression, which are prevalent in society today. Probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression. This review aims to discuss the development of the gut microbiota, the linkage of dysbiosis to anxiety and depression, and possible applications of probiotics to reduce symptoms.

Keywords

Microbiome; depression; anxiety; gut-brain-axis; dysbiosis.

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Submitted: 2017-06-09 22:09:51
Published: 2017-09-15 17:43:38
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Copyright (c) 2017 Megan Clapp, Nadia Aurora, Lindsey Herrera, Manisha Bhatia, Emily Wilen, Sarah Wakefield

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