Primary hypoparathyroidism presenting as basal ganglia calcification secondary to extreme hypocalcemia

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Edite Marques Mendes *
Lúcia Meireles-Brandão
Carla Meira
Nuno Morais
Carlos Ribeiro
Diana Guerra
(*) Corresponding Author:
Edite Marques Mendes |


Hypoparathyroidism is a rare endocrine disorder characterized by low serum calcium and parathyroid hormone levels. The most common cause is parathyroid iatrogenic surgical removal. However, innumerous and rarer conditions can cause hypoparathyroidism. The authors describe a 27-year-old man that presented in emergency department with confusion, amnesia and decreased attention span. A cerebral computed tomography revealed bilateral extensive calcification in the basal ganglia. A complete work-up revealed low serum calcium, high serum phosphorus and low parathyroid hormone, leading to the diagnosis of idiopathic primary hypoparathyroidism. Initial intravenous therapy with calcium gluconate and calcitriol was administered, with clinical and analytical improvement. The authors describe a rare condition, with an exuberant cerebral presentation and extreme hypocalcemia, which did not directly correlate to the severity of symptoms. Not only this is a treatable disorder that may have catastrophic results if overlooked but also its symptoms may be completely reversed with prompt treatment.

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Author Biography

Edite Marques Mendes, Department of Medicine - Medicine 1, Unit of Alto Minho, Santa Luzia Hospital, Viana do Castelo

Departamento de Medicina 1.