Take a second look: it's Kikuchi’s disease! A case report and review of literature

  • Oana Joean | Joean.Oana@mh-hannover.de Department of Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.
  • Thea Thiele Department of Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.
  • Mieke Raap Department of Pathology, Hannover Medical University, Hannover, Germany.
  • Reinhold E. Schmidt Department of Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.
  • Matthias Stoll Department of Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.

Abstract

Generalized lymphadenopathy is a common cause of concern for both patients and clinicians. Possible etiologies include infections, malignancies and autoimmune diseases. Kikuchi Fujimoto disease (KFD) is a hyperergic condition that presents with fever, lymphadenopathy and can include systemic involvement, thus being easily mistaken for the above-mentioned entities. We report the case of a previously healthy 18-year-old male who presented with a selflimiting generalized lymphadenopathy, high fevers, skin vasculitis and polyserositis. The lymph-node biopsy revealed a histiocytotic necrotizing lymphadenitis, suggestive of Kikuchi’s disease. This case emphasizes the importance of KFD in the differential diagnosis of lymphadenopathy, especially in young adults.

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Published
2018-12-12
Section
Case Reports
Keywords:
Kikuchi’s disease, Necrotising histiocytic lymphadenitis
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How to Cite
Joean, O., Thiele, T., Raap, M., Schmidt, R., & Stoll, M. (2018). Take a second look: it’s Kikuchi’s disease! A case report and review of literature. Clinics and Practice, 8(4). https://doi.org/10.4081/cp.2018.1095