Metabolic activity of intestinal microflora in patients with bronchial asthma

  • Vladimir Ivashkin Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Oxana Zolnikova | ks.med@mail.ru Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Nino Potskherashvili Vasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Alexander Trukhmanov Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Natalia Kokina Vasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Alla Sedova Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Elena Bueverova Chair of Internal Diseases Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Abstract

The gut microbiota plays the important role to support the immunological tolerance. To study a metabolic activity of the intestinal microflora the 44 patients suffering from bronchial asthma and 17 healthy volunteers were tested. The short-chain fatty acids (SCFA) spectrum was determined using the method of gas-liquid chromatographic analysis. We have detected a significant decrease the total content of the fatty acids in the feces (P<0.001), the absolute concentrations of the individual acids (acetate, propionate, butyrate; P<0.001) and the total content of isoacids (P<0.001) for all of the patients with bronchial asthma in the study, regardless of the phenotype. The anaerobic type of the SCFA spectrum was detected for the majority (83%) of the patients tested. The aerobic type of the SCFA metabolic profile was detected for another part (17%) of the patients tested. Being detected the parameters change could play the principal role as for the bronchial asthma course as to support the organism sensibilisation.

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Published
2019-02-28
Section
Brief Reports
Keywords:
Short-chain fatty acids, Gut microbiota, Bronchial asthma, Immunomodulation
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How to Cite
Ivashkin, V., Zolnikova, O., Potskherashvili, N., Trukhmanov, A., Kokina, N., Sedova, A., & Bueverova, E. (2019). Metabolic activity of intestinal microflora in patients with bronchial asthma. Clinics and Practice, 9(1). https://doi.org/10.4081/cp.2019.1126