Severe nephritis as initial sign of Waldenström’s macroglobulinemia
Waldenström’s macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.
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Copyright (c) 2019 Thomas Knoop, Kristin Kampevold Larsen, Friedemann Leh, Anette Lodvir Hemsing, Ingrid Anna Teigen, Håkon Reikvam
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