Severe nephritis as initial sign of Waldenström’s macroglobulinemia

  • Thomas Knoop Department of Medicine, Haukeland University Hospital; Institute of Medical Science, University of Bergen, Norway.
  • Kristin Kampevold Larsen Department of Pathology, Haukeland University Hospital, Norway.
  • Friedemann Leh Department of Pathology, Haukeland University Hospital, Norway.
  • Anette Lodvir Hemsing Department of Medicine, Haukeland University Hospital, Norway.
  • Ingrid Anna Teigen Department of Pharmacology, Haukeland University Hospital, Norway.
  • Håkon Reikvam | Hakon.Reikvam@med.uib.no Department of Medicine, Haukeland University Hospital; Institute of Clinical Science, University of Bergen, Bergen, Norway.

Abstract

Waldenström’s macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.

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Published
2019-12-19
Section
Case Reports
Keywords:
Nephrite, hypertension, proteinuria, Waldenström’s macroglobulinemia.
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How to Cite
Knoop, T., Larsen, K., Leh, F., Hemsing, A., Teigen, I., & Reikvam, H. (2019). Severe nephritis as initial sign of Waldenström’s macroglobulinemia. Clinics and Practice, 9(4). https://doi.org/10.4081/cp.2019.1184