Multiple doses of cell therapy and neurorehabilitation in amyotrophic lateral sclerosis: A case report

  • Alok Sharma NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Hemangi Sane NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Amruta Paranjape NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Radhika Pradhan | publications@neurogen.in NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Rohit Das NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Hema Biju NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Nandini Gokulchandran NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.
  • Prerna Badhe NeuroGen Brain and Spine Institute, Navi Mumbai, Maharashtra, India.

Abstract

Cell therapy, along with intensive rehabilitation has been shown to significantly improve outcomes in amyotrophic lateral sclerosis (ALS), in addition to standard therapy. We present a 40-years-old male ALS patient, suffering for the past four years, who underwent multiple doses of cell therapy at our institution. Along with riluzole treatment and lithium co-administration, his treatment involved multiple intrathecal transplants of autologous bone marrow-derived mononuclear cells, followed by multidisciplinary neurorehabilitation. The outcome measures of ALSFunctional Rating Scale Revised score remained stable, and importantly, Six Minute Walk Test distance improved from 475.2 m to 580.8 m, over a span of 16 months. Improved outcomes are indicative of slowing down of disease progression. Multiple doses of intrathecal autologous cell therapy along with rehabilitation and lithium, in addition to standard riluzole treatment is a novel approach for decelerating disease progression and qualitatively improving living conditions for ALS patients and their caregivers.

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Published
2020-09-28
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Section
Case Reports
Keywords:
Amyotrophic lateral sclerosis, bone marrow cells, cell therapy.
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How to Cite
Sharma, A., Sane, H., Paranjape, A., Pradhan, R., Das, R., Biju, H., Gokulchandran, N., & Badhe, P. (2020). Multiple doses of cell therapy and neurorehabilitation in amyotrophic lateral sclerosis: A case report. Clinics and Practice, 10(3). https://doi.org/10.4081/cp.2020.1242