Gangrene of the digits of the right lower limb in a patient with homozygous sickle cell disease and ulcerative colitis

  • Angela E. Rankine-Mullings | angela.rankinemullings@uwimona.edu.jm Sickle Cell Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Kingston, Jamaica.
  • Jennifer M. Knight-Madden Sickle Cell Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Kingston, Jamaica.
  • Marvin Reid Tropical Metabolism Research Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Kingston, Jamaica.
  • Trevor S. Ferguson Epidemiology Research Unit, Tropical Medicine Research Institute (TMRI), University of the West Indies, Mona, Jamaica.

Abstract

Thrombosis may play an important role in the pathophysiology of certain complications of sickle cell disease (SCD). While the association between SCD and ulcerative colitis (UC) is still debatable, inflammatory bowel disease is known to be associated with an increased incidence of thromboembolic disease. We report a case of a 16-year old girl known to have homozygous SCD and also diagnosed with UC who presented with digital ischemia of her right lower limb. This led to gangrene and subsequent amputation of the first, second and third digits of that limb. This case highlights that patients with both UC and SCD may have an increased risk of thromboembolism and raises the question as to whether patients with UC and SCD should be screened for thrombophilia.

Downloads

Download data is not yet available.
Published
2014-04-03
Section
Case Reports
Keywords:
gangrene, homozygous sickle cell disease, ulcerative colitis, digital ischaemia, thromboembolic disease.
Statistics
Abstract views: 728

PDF: 418
HTML: 195
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Rankine-Mullings, A., Knight-Madden, J., Reid, M., & Ferguson, T. (2014). Gangrene of the digits of the right lower limb in a patient with homozygous sickle cell disease and ulcerative colitis. Clinics and Practice, 4(1). https://doi.org/10.4081/cp.2014.610