Acute respiratory failure as primary manifestation of antineutrophil cytoplasmic antibodies-associated vasculitis

  • Evdokia Sourla Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Vasilis Bagalas Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Helias Tsioulis Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Asimina Paspala Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Sofia Akritidou Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Athanasia Pataka Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Katalin Fekete Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Ioannis Kioumis Department of Pneumonology, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki,, Greece.
  • Ioannis Stanopoulos Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.
  • Georgia Pitsiou | gpitsiou@yahoo.gr Respiratory Intensive Care Unit, Aristotle University of Thessaloniki, G.H. “G. Papanikolaou”, Thessaloniki, Greece.

Abstract

The systemic vasculitides are multifocal diseases characterized by the presence of blood vessel inflammation in multiple organ systems. Their clinical presentation is variable extending from self-limited illness to critical complications including diffuse alveolar hemorrhage and glomerulonephritis. Alveolar hemorrhage is a lifethreatening manifestation of pulmonary vasculitis that can rapidly progress into acute respiratory failure requiring ventilatory support. We present the case of a 74-year-old patient admitted to the Intensive Care Unit with severe hypoxic respiratory failure and diffuse alveolar infiltrates in chest imaging that was later diagnosed as antineutrophil cytoplasmic antibodies-associated vasculitis. The report highlights the importance of differentiate between alveolar hemorrhage and acute respiratory distress syndrome of other etiology because alveolar hemorrhage is reversible with prompt initiation of treatment.

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Published
2014-07-04
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Section
Case Reports
Keywords:
respiratory failure, vasculitis, antineutrophil cytoplasmic antibodies, alveolar infiltrates.
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How to Cite
Sourla, E., Bagalas, V., Tsioulis, H., Paspala, A., Akritidou, S., Pataka, A., Fekete, K., Kioumis, I., Stanopoulos, I., & Pitsiou, G. (2014). Acute respiratory failure as primary manifestation of antineutrophil cytoplasmic antibodies-associated vasculitis. Clinics and Practice, 4(2). https://doi.org/10.4081/cp.2014.653