Granulomatous lithiasic cholecystitis in sarcoidosis

  • Adriana Handra-Luca | Department of Pathology, Paris Public Assistance Hospitals, North Paris Sorbonne Cité University, Avicenne Hospital University Group, Bobigny, France.


Gallbladder granulomas are exceedingly rare, reported in association with tuberculosis or sarcoidosis. Here we report a case of gallbladder granulomatous cholecystitis occurring in the context of sarcoidosis. A 70-years old man presented with abdominal pain, nausea and vomiting. The medical history revealed sarcoidosis diagnosed more than 20-years previously. 2-years previously the patient showed renal lithiasis, hypercalcemia and, increased angiotensin converting enzyme. The imaging features suggested thoraco-abdominal sarcoidosis. Prednisone was given at 1.2 mg/kg/day initially, than decreased, being at 2.5 mg/day at present. The ultrasound examination showed gallbladder lithiasis. A cholecystectomy was performed. Microscopy showed subacute and chronic cholecystitis with several epithelioid and giant cell granulomas some of them perineural. In conclusion, we report a case of granulomatous cholecystitis occurring in the course of treated sarcoidosis. The perineural location of granulomas may give further insights into the pathogenesis of gallbladder dysmotility.


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Case Reports
Gallbladder, cholecystitis, lithiasis, granuloma, nerve, perineural, sarcoidosis.
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How to Cite
Handra-Luca, A. (2016). Granulomatous lithiasic cholecystitis in sarcoidosis. Clinics and Practice, 6(1).