Non-pharmacologic approach to prevent embolization in patients with atrial fibrillation in whom anticoagulation is contraindicated

  • Munish Sharma | Department of Internal Medicine, Easton Hospital, Easton, PA, United States.
  • Koroush Khalighi Department of Cardiology, Easton Hospital and Clinical Medicine, Drexel University College of Medicine, Easton, PA, United States.


Ischemic stroke is the most common complication of atrial fibrillation (AF). Anticoagulation therapy reduces the risk of systemic embolization in almost all patients with AF irrespective of the type of AF (paroxysmal, persistent or permanent). But, all patients are not suitable candidates for systemic anticoagulation mainly due to the risk of bleeding. Left atrial appendage closure (LAAC) devices have been found to be very effective non-pharmacologic alternative therapy for such patients. There are various types of LAAC devices but United States Food and Drug Administration (USFDA) have approved only Watchman device. Initially, bigger medical centers in the US had started the insertion of Watchman device but with improving procedural techniques and exciting outcomes, even the community-based hospitals have started to embrace this therapy. We have presented the first three cases of Watchman device placement performed in our hospital and discussed about the indications for placement of LAAC devices .We have also reviewed their efficacy individually.


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Case Reports
Non-valvular atrial fibrillation, warfarin, Watchman device, ischemic stroke, novel oral anticoagulants.
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How to Cite
Sharma, M., & Khalighi, K. (2017). Non-pharmacologic approach to prevent embolization in patients with atrial fibrillation in whom anticoagulation is contraindicated. Clinics and Practice, 7(1).

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