Investigating idiopathic inflammatory myopathy; initial cross speciality experience with use of the extended myositis antibody panel

  • Antoinette O'Connor | antoinetteoconnor.aoc@gmail.com Department of Neurology, Cork University Hospital, Cork, Ireland.
  • Jennifer Mulhall Department of Neurology, Cork University Hospital, Cork, Ireland.
  • Sinead M.J. Harney Department of Rheumatology, Cork University Hospital, Cork, Ireland.
  • John G. Ryan Department of Rheumatology, Cork University Hospital, Cork, Ireland.
  • Grainne Murphy Department of Rheumatology, Cork University Hospital, Cork, Ireland.
  • Michael T. Henry Department of Respiratory Medicine, Cork University Hospital, Cork, Ireland.
  • Peter Annis Department of Immunology, Cork University Hospital, Cork, Ireland.
  • Vincent Tormey Department of Immunology, University Hospital, Galway, Ireland.
  • Aisling Ryan Department of Neurology, Cork University Hospital, Cork, Ireland.

Abstract

The discovery of unique autoantibodies has informed and altered our approach to the diagnosis and management of the inflammatory myopathies. This study reports the initial clinical experience of use of the Extended Myositis Antibody (EMA) panel in the largest university teaching hospital in Ireland. We conducted a retrospective review of all patients who had serum samples tested for myositis specific antibodies and myositis associated antibodies from April 2014 to March 2015. A positive EMA panel was of significant clinical utility in facilitating decisions on appropriate investigations, and need for onward referral to other physicians. Furthermore, this paper highlights the diversity of possible presentations of idiopathic inflammatory myopathy with subsequent need for multi-speciality involvement, and serves to heighten awareness among clinicians of the diagnostic use of extended myositis antibody testing in these cases.

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Author Biography

Antoinette O'Connor, Department of Neurology, Cork University Hospital, Cork
Neurology Specialist Registrar
Published
2017-05-04
Section
Brief Reports
Keywords:
Idiopathic inflammatory myopathy, myositis specific autoantibodies, myositis- associated autoantibodies.
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How to Cite
O’Connor, A., Mulhall, J., Harney, S. M., Ryan, J. G., Murphy, G., Henry, M. T., Annis, P., Tormey, V., & Ryan, A. (2017). Investigating idiopathic inflammatory myopathy; initial cross speciality experience with use of the extended myositis antibody panel. Clinics and Practice, 7(2). https://doi.org/10.4081/cp.2017.922