Primary sclerosing cholangitis and pregnancy

  • Casper Q. Kammeijer Department of Obstetrics and Gynecology, Bronovo Hospital, The Hague, Netherlands.
  • Robert A. De Man Department of Gastroenterology, Erasmus Medical Center Rotterdam, Netherlands.
  • Christianne J.M. De Groot | Department of Obstetrics and Gynecology, Free University Medical Center, Amsterdam, Netherlands.


Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure. A rare case of primary sclerosing cholangitis in pregnancy is presented. The course of the pregnancy was marked by threatened preterm delivery and exacerbation of cholestasis. She was successfully treated with ursodeoxycholic acid (UDCA). Although, primary sclerosing cholangitis has both maternal and fetal effects on pregnancy, the overall outcome is favorable. Only few cases have been reported using high dose ursodeoxycholic acid for primary sclerosing cholangitis in pregnancy, it often improves pruritus but has no protection against stillbirth. Data on the safety to the fetus or neonate and long-term outcome are scarce.


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Case Reports
pregnancy, sclerosing cholestasis, ursodeoxycholic acid.
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How to Cite
Kammeijer, C., De Man, R., & De Groot, C. (2011). Primary sclerosing cholangitis and pregnancy. Clinics and Practice, 1(3), e55.