Clinical response to glycyrrhizinic acid in genital infection due to human papillomavirus and low-grade squamous intraepithelial lesion

  • Marcelino Hernandez Valencia | mhernandezvalencia@prodigy.net.mx Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F., Mexico.
  • Adia Carrillo Pacheco Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F., Mexico.
  • Tomás Hernández Quijano Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F., Mexico.
  • Antonio Vargas Girón Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F., Mexico.
  • Carlos Vargas López Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F., Mexico.

Abstract

Human papilloma virus (HPV) can infect any of the mucosal areas of the body and cause cervical cancer. Until recently, no specific treatments were available for this condition; therefore, any damaged tissue had to be removed or destroyed, which may have presented obstetrical repercussions for some women. Recently, new drugs have been developed that have shown to be effective for the cure of HPV infection. Glycyrrhizinic acid (GA) has shown fewer side effects and its systemic use makes it possible to reach difficultto- treat lesions. The purpose of this study was to evaluate the clinical outcome of GA to eliminate the epithelial lesion and HPV. We carried out a longitudinal, descriptive study that included women of reproductive age who were diagnosed with HPV associated with low-grade squamous intraepithelial lesion (LSIL). Subjects began treatment based on GA using two routes of administration - systemic (oral) and topical (spray) - with assessments every month to determine the clinical changes of the lesions through colposcopy and Papanicolaou (Pap) smear. Simple statistics were used along with two-tailed Student’s t-test; P<0.05 was considered statistically significant before and after treatment. There were 70 eligible patients, of whom 62 fulfilled the inclusion criteria. Age of subjects was 27.8±9.5 years. At the time of the study, 100% of the patients had HPV infection, 40% were associated with LSIL, and only 16% used a barrier contraceptive (condom) method. Resolution was achieved in all patients from 4 weeks of treatment initiation and improvement was achieved in the majority of patients at 12 weeks (74%) (P<0.001). However, there was persistence of LSIL in 27.7% of patients and only one patient progressed to cervical intraepithelial neoplasia (CIN) II. The use of GA proved to be effective in resolving clinical HPV lesions. For cervical lesions with epithelial changes (LSIL), treatment may be required for a longer period as with other drugs used for this infection, as well as monitoring for at least 1 year according to the natural evolution of the disease.

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Author Biography

Marcelino Hernandez Valencia, Hospital General de Ecatepec Dr. José Ma. Rodríguez, ISEM y Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, CMN Siglo XXI, IMSS, México, D.F.

Unit of Endocrine Research, National Medical Center, Instituto Mexicano del Seguro social.

MD and PhD, Medical research, Ginecologist Endocrinology

Published
2011-11-08
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Keywords:
human papilloma virus, low-grade squamous intraepithelial lesion, glycyrrhizinic acid.
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How to Cite
Valencia, M. H., Pacheco, A. C., Quijano, T. H., Girón, A. V., & López, C. V. (2011). Clinical response to glycyrrhizinic acid in genital infection due to human papillomavirus and low-grade squamous intraepithelial lesion. Clinics and Practice, 1(4), e93. https://doi.org/10.4081/cp.2011.e93