Clinics and Practice 2019-09-18T23:27:46+02:00 Francesca Baccino Open Journal Systems <p><strong>Clinics and Practice</strong>&nbsp;[ISSN 2039-7283] is a peer-reviewed, Open Access, online-only journal that publishes both&nbsp;<em>brief reports</em>&nbsp;and&nbsp;<em>case reports</em>&nbsp;in all areas of clinical medicine. Our journal would welcome any interesting description of patients, procedures and treatment in any condition or disease that can contribute to develop scientifically rigorous and clinically meaningful practice methods. <br><strong>Clinics and Practice</strong> aims at creating an innovative, rapid and collaborative background intended to help healthcare professionals finding the latest advances to answer the most pressing questions coming from the medicine/patients relationship.</p> Diode laser assisted excision of a gingival pyogenic granuloma: A case report 2019-09-18T23:27:44+02:00 Dimitrios Andreadis Ioanna Lazaridi Eleftherios Anagnostou Athanasios Poulopoulos Prashanth Panta Shankargouda Patil <p>exuberant, reactive lesion seen in response to local irritation or trauma caused by dental calculus, bacterial plaque, caries and restorations, with a strong predilection for the gingiva. It is among the frequently encountered oral lesions, occurring at a challenging oral site, the gingiva. Herein, we report a 71-year-old medically compromised Caucasian female who presented with a relatively large lobulated pyogenic granuloma on the buccal gingiva of the maxillary molar-premolar region. Total surgical excision was performed with an 840nm diode laser followed by the placement of hyaluronate gel and relevant periodontal dressing. Two weeks after surgical excision, complete healing was observed, but patient denied replacement of dental restoration. After 4 months of follow-up, an overall reduction of associated teeth mobility was also observed, with a minor recurrence in gingival inflammation. The objective of this report is to briefly review clinical, radiographic and histological findings of pyogenic granuloma along with a detailed discussion on its management through a diode laser.</p> 2019-08-27T00:00:00+02:00 ##submission.copyrightStatement## An unusual infection in an immunocompetent male from a non-endemic area: Lessons from a vacation 2019-09-18T23:27:45+02:00 Ritesh Neupane Munish Sharma Divakar Sharma Rajeev Thachil Mahesh Krishnamurthy Gerald Lowman <p>Primary pulmonary histoplasmosis is found worldwide, and is particularly endemic in some areas of the North America, usually those surrounding the Ohio and Mississippi river valleys. It is not common in the East Coast of the United States, and is in fact, reportable in Pennsylvania. It has been rarely described in immunocompetent individuals residing in a non-endemic region. We present a case of a previously healthy middle-aged male, a Pennsylvania resident, who presented with mid-sternal chest discomfort, fatigue, chills and mild shortness of breath, and was diagnosed with primary pulmonary histoplasmosis.</p> 2019-08-09T13:58:53+02:00 ##submission.copyrightStatement## Mycoplasma pneumoniae-associated transverse myelitis presenting as asymmetric flaccid paralysis 2019-09-18T23:27:44+02:00 Shafee Salloum Ajay Goenka Elizabeth Ey <p>Acute transverse myelitis is a rare spinal cord inflammatory disorder that manifests as sudden onset of motor, sensory, and autonomic dysfunctions. Here, we report a case of acute transverse myelitis in a 13-year-old boy secondary to <em>Mycoplasma pneumoniae</em> infection. He presented with left facial palsy and contralateral upper extremity weakness without sensory or autonomic changes. The patient was diagnosed with transverse myelitis based on his magnetic resonance imaging findings, although his presentation was mainly motor dysfunction, which is more consistent with acute flaccid paralysis.</p> 2019-09-12T12:02:05+02:00 ##submission.copyrightStatement## Giant aggressive forehead tumor: A 15-year follow-up 2019-09-18T23:27:46+02:00 Raymond Challita Said Halabi <p>Proliferating trichilemmal tumors are rare tumors that originate from adnexal structures – specifically from the outer root sheaths of hair follicles. These tumors can be benign or malignant. We report a rare case of a giant aggressive forehead trichilemmal tumor that was paradoxically benign on pathology. It was surgically excised and followed-up for 15 years.</p> 2019-08-02T10:33:18+02:00 ##submission.copyrightStatement## Cardiac papillary fibroelastoma of a bicuspid aortic valve in an adolescent: A case report 2019-09-18T23:27:46+02:00 Sarah Dénes Benoît Daron Marie Behaeghe Marie-Christine Seghaye <p>Cardiac papillary fibroelastomas (CPFE) are exceptional primary benign cardiac tumours affecting the heart valves. We report here the case of a 15-year-old boy in whom echocardiography performed for non-specific chest pain during follow-up for bicuspid aortic valve showed as accidental finding the presence of a round mobile mass without stalk attached on the inferior side of the aortic valve. The mass did not cause any outflow tract obstruction or aortic insufficiency. Electrocardiogram-gated cardiac computed tomography and magnetic resonance imaging allowed to suspect CPFE. Although the patient was asymptomatic, open cardiac surgery with elective surgical resection of the tumour was performed to avoid systematic emboli. Histology confirmed the diagnosis of CPFE. This is an exceptional case of acquired CPFE in a young patient with bicuspid aortic valve. Due to the risk of systemic embolization, aortic or coronary ostium obstruction, elective excision of such lesions is recommended.</p> 2019-08-07T16:25:18+02:00 ##submission.copyrightStatement## Acute eosinophilic appendicitis after generalized skin reaction due to unknown cause in a child: Case report and literature review 2019-09-18T23:27:43+02:00 Maria Aggelidou Katerina Kambouri Maria Kouroupi Dimitrios Cassimos Soultana Foutzitzi Savas Deftereos <p>Acute eosinophilic appendicitis (AEA) is a rare variant of appendix inflammation possibly linked to allergy. Histopathological evidence of eosinophilic infiltration of the <em>muscularis propria</em> and edema separating the muscle fibers is the gold standard for the diagnosis. Here, we report a case of a young boy with AEA following a skin reaction of possible allergic origin. A 6-year-old male was presented to the emergency department with a two-day diffuse abdominal pain and tenderness in the right lower quadrant. A possible allergic reaction had occurred five days before as a pruritic rash. There was no history of allergy and the stool examination was negative for parasites. The initial diagnosis was acute appendicitis, and appendectomy was performed. The histopathological diagnosis was AEA. Further studies on the proper diagnostic and treatment approach of AEA before surgery are required.</p> 2019-09-16T15:27:06+02:00 ##submission.copyrightStatement## Ewing's sarcoma with distant metastasis: A brief note on management and emerging therapies 2019-09-18T23:27:42+02:00 Girish Gulab Meshram Neeraj Kaur Kanwaljeet Singh Hura <p>Ewing’s sarcoma is an aggressive fatal malignancy of bones and soft-tissue. It predominantly affects the young population, with a worldwide incidence of three cases per million. The pelvis, extremities, and ribs are the most common sites. We present a case of massive Ewing’s sarcoma of the right femur with metastasis to bones and lungs. The patient was treated with chemotherapy. However, he succumbed to his illness before completion of therapy. In conclusion, Ewing’s sarcoma with distant metastasis is a high risk case with poor prognosis. Integrating novel molecular targets with conventional chemotherapeutic agents holds a promise for high-risk Ewing’s sarcoma patients.</p> 2019-09-17T10:32:39+02:00 ##submission.copyrightStatement##